Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 17/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15854649 | 0.79 | PIM1 (0.53) | PIM1PIM2PIM3 | |
| SCHEMBL15854652 | 0.78 | PIM1 (0.65) | PIM1PIM2PIM3 | |
| SCHEMBL15854660 | 0.75 | GUSB (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL15854705 | 0.74 | PIM1 (0.60) | PIM1PIM2PIM3 | |
| SCHEMBL15854700 | 0.74 | PIM1 (0.59) | PIM1PIM2PIM3S1PR1 | |
| SCHEMBL15854687 | 0.73 | PIM1 (0.41) | PIM1PIM2PIM3 | |
| SCHEMBL15854650 | 0.72 | PIM1 (0.38) | PIM1PIM2PIM3 | |
| SCHEMBL15854692 | 0.72 | PIM1 (0.37) | PIM1PIM2PIM3 | |
| SCHEMBL15854669 | 0.72 | PIM1 (0.48) | PIM1PIM2PIM3S1PR1 | |
| SCHEMBL15854668 | 0.72 | PIM1 (0.48) | PIM1PIM2PIM3S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9321756-B2 | Azole compounds as PIM inhibitors | AMGEN INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20140187553-A1 | Azole Compounds as PIM Inhibitors | AMGEM INC. (US) | 2014-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187553-A1 | Azole Compounds as PIM Inhibitors | PIM1, PIM3, PIM2 | PIM1 1/4885PIM2 3/4885PIM3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.