Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.64 |
| ▸ | CDK8 | P49336 | 2/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | ROS1 | P08922 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | LTK | P29376 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | MERTK | Q12866 | 2/20 | 0.50 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15870580 | 0.88 | CCNC (0.61) | CCNCCDK8CNR1FGFR1FGFR2 | |
| SCHEMBL15870552 | 0.87 | CCNC (0.64) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15870515 | 0.87 | CCNC (0.64) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15870506 | 0.87 | CCNC (0.64) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15864598 | 0.85 | CCNC (0.66) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15870510 | 0.85 | CCNC (0.53) | CCNCCDK8CNR1FGFR1FGFR2 | |
| SCHEMBL15870566 | 0.85 | CDK8 (0.61) | CCNCCDK8FDPSCDK9CDK2 | |
| SCHEMBL15870532 | 0.84 | CCNC (0.63) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15870567 | 0.84 | CCNC (0.60) | CCNCCDK8FGFR1FGFR2FGFR3 | |
| SCHEMBL15870509 | 0.84 | CCNC (0.60) | CCNCCDK8FGFR2EGFRFDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014106606-A1 | NOVE PHENYL/PYRIDINE SERIES SUBSTITUED BY HYDROXYETHYLAMINO FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-07-10 | — | — | WO | disclosed |