Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.40 |
| ▸ | HTR2B | P41595 | 4/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FLT1 | P17948 | 4/20 | 0.39 |
| ▸ | FLT4 | P35916 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | TEK | Q02763 | 2/20 | 0.37 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL983574 | 0.94 | EGFR (0.39) | HTR2AHTR2BHTR2CEGFRFGFR1 | |
| SCHEMBL985007 | 0.87 | KCNH2 (0.36) | HTR2AHTR2BHTR2CEGFRFGFR1 | |
| SCHEMBL31027311 | 0.85 | SCD (0.42) | HTR2AHTR2BHTR2CFFAR4CNR2 | |
| SCHEMBL21957402 | 0.85 | SCD (0.42) | HTR2AHTR2BHTR2CFFAR4CNR2 | |
| SCHEMBL984670 | 0.82 | PDE4B (0.43) | PDE4BPDE4D | |
| SCHEMBL9896972 | 0.79 | SCN9A (0.36) | HTR2AHTR2BHTR2CRETCNR2 | |
| SCHEMBL18152879 | 0.75 | SCN9A (0.46) | — | |
| SCHEMBL983839 | 0.74 | TDP1 (0.47) | SLC6A4PDE4BPDE4D | |
| SCHEMBL983941 | 0.73 | HTR2C (0.51) | HTR2AHTR2BHTR2CSLC6A4FFAR4 | |
| SCHEMBL981699 | 0.73 | TDP1 (0.46) | SLC6A4PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609065-B1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | ALBEMARLE CORP (US) | 2015-07-08 | — | — | EP | claimed |
| EP-2609065-A1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | Albemarle Corporation (US) | 2013-07-03 | — | — | EP | claimed |
| US-20130109887-A1 | PROCESSES FOR PRODUCING 1-BROMO-2- (CYCLOPROPYL METHOXY)-5-FLUORO-4-METHOXYBENZENE | ALBERMARLE CORPORATION (US) | 2013-05-02 | — | — | US | claimed |
| WO-2012027134-A1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | ALBEMARLE CORPORATION (US) | 2012-03-01 | — | — | WO | claimed |
| US-9376442-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| EP-2609065-B1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | ALBEMARLE CORP (US) | 2015-07-08 | — | — | EP | disclosed |
| CN-103201244-B | Processes for producing 1-bromo-2 (cyclopropyl methoxy)-5 fluoro-4- methoxybenzene | ALBEMARLE CORP | 2015-06-17 | — | — | CN | disclosed |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8927557-B2 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2015-01-06 | — | — | US | disclosed |
| EP-2470536-B1 | Methylpyrrolopyrimidinecarboxamides | TAKEDA GMBH (DE) | 2014-11-12 | — | — | EP | disclosed |
| US-8816085-B2 | Methylpyrrolopyridinecarboxamides | TAKEDA GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| CN-103201244-A | Processes for producing 1-bromo-2 (cyclopropyl methoxy)-5 fluoro-4- methoxybenzene | ALBEMARLE CORP | 2013-07-10 | — | — | CN | disclosed |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2012-06-07 | — | — | US | disclosed |
| WO-2012027134-A1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | ALBEMARLE CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012027134-A1 | PROCESSES FOR PRODUCING 1-BROMO-2 (CYCLOPROPYL METHOXY)-5 FLUORO-4- METHOXYBENZENE | ALBEMARLE CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |
| WO-2011023693-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
| WO-2011023696-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-03-03 | — | — | WO | disclosed |
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2011-01-27 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021479-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | HTR2A 3062/4885HTR2B 1921/4885HTR2C 1834/4885 |
| US-20130109887-A1 | PROCESSES FOR PRODUCING 1-BROMO-2- (CYCLOPROPYL METHOXY)-5-FLUORO-4-METHOXYBENZENE | CYP4B1, CYP4X1, CYP1B1 | HTR2A 1232/4885HTR2B 233/4885HTR2C 603/4885 |
| US-20120142633-A1 | METHYLPYRROLOPYRIDINECARBOXAMIDES | PDE5A, PDE3A, PDE2A | HTR2A 1891/4885HTR2B 1305/4885HTR2C 1128/4885 |
| US-20150073001-A1 | METHYLPYRROLOPYRIMIDINECARBOXAMIDES | PDE12, PDE5A, PDE4A | HTR2A 3746/4885HTR2B 2850/4885HTR2C 2569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.