Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SERPINH1 | P50454 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15391354 | 0.89 | PDE5A (0.44) | EZH2MEN1KMT2AOPRK1PDE5A | |
| SCHEMBL15871014 | 0.88 | EZH2 (0.43) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL17201384 | 0.88 | EZH2 (0.43) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL17208276 | 0.88 | EZH2 (0.43) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL15871020 | 0.86 | EZH2 (0.58) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL17201378 | 0.86 | EZH2 (0.58) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL17208277 | 0.86 | EZH2 (0.58) | EZH2RORCMEN1KMT2AOPRK1 | |
| SCHEMBL15864890 | 0.86 | KAT2B (0.46) | EZH2MEN1KMT2AOPRK1 | |
| SCHEMBL15864876 | 0.86 | EZH2 (0.43) | EZH2MEN1KMT2A | |
| SCHEMBL15864924 | 0.85 | ATM (0.46) | EZH2MEN1KMT2AOPRK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014107277-A1 | ENHANCER OF ZESTE HOMOLOG 2 INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-07-10 | — | — | WO | disclosed |