Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 3/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19788400 | 0.85 | CDC7 (0.57) | TGM2NAMPTCDC7DBF4CDK2 | |
| SCHEMBL14311088 | 0.77 | CDC7 (0.48) | TGM2NAMPTCDC7DBF4CDK2 | |
| SCHEMBL14289643 | 0.73 | JAK2 (0.41) | NAMPTCDC7DBF4CDK2CCNE1 | |
| SCHEMBL12321651 | 0.73 | PDPK1 (0.49) | CDC7DBF4CDK2CCNE1CAMKK2 | |
| SCHEMBL22246542 | 0.72 | NPC1 (0.51) | TGM2NAMPTADORA2ABTKROCK1 | |
| SCHEMBL16785551 | 0.72 | HDAC1 (0.45) | EPHX1HDAC1TNKSTNKS2 | |
| SCHEMBL7742679 | 0.71 | NAMPT (0.68) | NAMPTEPHX1HDAC1 | |
| SCHEMBL19788401 | 0.70 | ADORA2A (0.55) | TGM2NAMPTADORA2AHDAC1MAPK1 | |
| SCHEMBL16775744 | 0.70 | ATM (0.43) | EPHX1 | |
| SCHEMBL5790114 | 0.69 | HDAC1 (0.74) | NAMPTEPHX1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778977-B2 | Pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2014-07-15 | — | — | US | disclosed |