Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | TTR | P02766 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15877347 | 0.81 | GRM5 (0.64) | GRM5KCNH2TTRSMN1; SMN2CYP1A2 | |
| SCHEMBL15877102 | 0.80 | GRM5 (0.63) | GRM5KCNH2TTRNPC1RAB9A | |
| SCHEMBL15877252 | 0.77 | GRM5 (1.00) | GRM5KCNH2TTRNPC1RAB9A | |
| SCHEMBL15877625 | 0.76 | GRM5 (0.58) | GRM5KCNH2TTRNPC1RAB9A | |
| SCHEMBL30833070 | 0.75 | GRM5 (0.54) | GRM5NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL3955825 | 0.75 | GRM5 (0.54) | GRM5NPC1RAB9ATP53SMN1; SMN2 | |
| SCHEMBL18685683 | 0.75 | TTR (0.59) | GRM5KCNH2TTRCYP1A2NCF1 | |
| SCHEMBL30824514 | 0.74 | GRM5 (0.59) | GRM5KCNH2TTRNPC1RAB9A | |
| SCHEMBL12884286 | 0.74 | GRM5 (0.65) | GRM5KCNH2TTRNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL4309309 | 0.74 | GRM5 (0.53) | GRM5NPC1RAB9ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946431-B2 | 2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-02-03 | — | — | US | claimed |
| US-20140206876-A1 | 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-24 | — | — | US | claimed |
| US-8946431-B2 | 2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2015-02-03 | — | — | US | disclosed |
| US-20140206876-A1 | 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140206876-A1 | 2-(Substituted ethynyl)quinoline Derivatives as mGLUr5 Antagonists | GRM5, GRIK5, GRIA4 | GRM5 1/4885KCNH2 1318/4885TTR 3319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.