SCHEMBL158782

SCHEMBL158782

CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCCC1C(=O)Nc1cc2c(NCc3ccccc3)ncnc2cc1OC)C(C)(C)C

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.81
CYP2C9 P11712 2/20 0.77
XIAP P98170 2/20 0.77
CYP2C19 P33261 1/20 0.77
EGFR P00533 7/20 0.52
ERBB4 Q15303 1/20 0.45
BIRC2 Q13490 5/20 0.45
BIRC3 Q13489 1/20 0.45
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
HTT P42858 1/20 0.44
LCK P06239 2/20 0.44
ABL1 P00519 1/20 0.42
RAF1 P04049 1/20 0.42
ERBB2 P04626 1/20 0.42
RET P07949 1/20 0.42
SRC P12931 1/20 0.42
FGFR2 P21802 1/20 0.42
FLT4 P35916 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL159250 1.00 CYP3A4 (0.81) CYP3A4CYP2C9XIAPCYP2C19EGFR
SCHEMBL159251 1.00 CYP3A4 (0.81) CYP3A4CYP2C9XIAPCYP2C19EGFR
Hydrochloric Acid SCHEMBL159428 0.99 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR
Hydrochloric Acid SCHEMBL15050286 0.99 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR
Hydrochloric Acid SCHEMBL15050287 0.99 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR
SCHEMBL15075568 0.94 CYP3A4 (0.84) CYP3A4CYP2C9XIAPCYP2C19EGFR
Hydrochloric Acid SCHEMBL159704 0.94 CYP3A4 (0.71) CYP3A4CYP2C9XIAPCYP2C19EGFR
SCHEMBL156665 0.90 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR
SCHEMBL158420 0.90 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR
SCHEMBL156666 0.90 CYP3A4 (0.80) CYP3A4CYP2C9XIAPCYP2C19EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611797-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS Hanmi Science Co., Ltd. (KR) 2013-07-10 EP claimed
WO-2012030160-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS HANMI HOLDINGS CO., LTD. (KR) 2012-03-08 WO claimed
EP-2611797-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS Hanmi Science Co., Ltd. (KR) 2013-07-10 EP disclosed
WO-2012030160-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS HANMI HOLDINGS CO., LTD. (KR) 2012-03-08 WO disclosed