Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.54 |
| ▸ | DDAH1 | O94760 | 4/20 | 0.50 |
| ▸ | NOS2 | P35228 | 6/20 | 0.49 |
| ▸ | NOS1 | P29475 | 6/20 | 0.49 |
| ▸ | NOS3 | P29474 | 5/20 | 0.49 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL27996908 | 1.00 | OTC (0.54) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL4332185 | 1.00 | OTC (0.54) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL15889 | 1.00 | OTC (0.54) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL28725103 | 1.00 | OTC (0.54) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL2729038 | 1.00 | OTC (0.54) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL23608085 | 0.98 | OTC (0.53) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL17629209 | 0.98 | OTC (0.53) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL28165841 | 0.98 | OTC (0.53) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL16486916 | 0.98 | OTC (0.53) | OTCDDAH1NOS2NOS1NOS3 | |
| Arginine SCHEMBL423342 | 0.98 | OTC (0.53) | OTCDDAH1NOS2NOS1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4231 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025264432-A1 | METHODS FOR TREATING DENTAL HYPERSENSITIVITY | COLGATE-PALMOLIVE COMPANY (US) | 2025-12-26 | — | — | WO | claimed |
| US-20250332107-A1 | IMMEDIATE RELEASE DOSAGE FORM | KENVUE BRANDS LLC (US) | 2025-10-30 | — | — | US | claimed |
| EP-4640204-A2 | HAIR COSMETIC COMPOSITION | Kao Corporation (JP) | 2025-10-29 | — | — | EP | claimed |
| EP-3831362-B1 | HAIR COSMETIC COMPOSITION | KAO CORP (JP) | 2025-10-15 | — | — | EP | claimed |
| EP-4603150-A2 | ORAL CARE PRODUCT AND METHODS OF USE AND MANUFACTURE THEREOF | Colgate-Palmolive Company (US) | 2025-08-20 | — | — | EP | claimed |
| EP-4591943-A2 | ORAL CARE COMPOSITIONS AND METHODS FOR THE SAME | Colgate-Palmolive Company (US) | 2025-07-30 | — | — | EP | claimed |
| EP-3883540-B1 | ORAL CARE COMPOSITIONS AND METHODS FOR THE SAME | COLGATE PALMOLIVE CO (US) | 2025-07-23 | — | — | EP | claimed |
| US-12296049-B2 | Immediate release dosage form | KENVUE BRANDS LLC (US) | 2025-05-13 | — | — | US | claimed |
| CN-106714783-B | Effervescent composition and method for preparing same | 驶帝生命科学印度私人有限公司 | 2025-04-18 | — | — | CN | claimed |
| EP-3373901-B2 | DENTIFRICE COMPOSITIONS WITH IMPROVED FLUORIDE UPTAKE | PROCTER & GAMBLE (US) | 2025-01-15 | — | — | EP | claimed |
| EP-0954292-A1 | PHARMACEUTICAL FORMULATIONS WITH DELAYED DRUG RELEASE | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1999-11-10 | — | — | EP | claimed |
| CN-1227483-A | Anti-caries oral compositions | UNIV NEW YORK STATE RES FOUND (US) | 1999-09-01 | — | — | CN | claimed |
| EP-0928184-A1 | ANTI-CARIES ORAL COMPOSITIONS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1999-07-14 | — | — | EP | claimed |
| US-5788987-A | TIME-SPECIFIC CONTROLLED RELEASE DOSAGE FORMULATION | POLI INDUSTRIA CHIMICA SPA (IT) | 1998-08-04 | — | — | US | claimed |
| WO-1998032425-A1 | PHARMACEUTICAL FORMULATIONS WITH DELAYED DRUG RELEASE | POLI INDUSTRIA CHIMICA S.P.A. (US) | 1998-07-30 | — | — | WO | claimed |
| WO-1997032565-A1 | ANTI-CARIES ORAL COMPOSITIONS | THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK (US) | 1997-09-12 | — | — | WO | claimed |
| CN-1121314-A | Improvements in or relating to contrast agents | NYCOMED IMAGING AS (NO) | 1996-04-24 | — | — | CN | claimed |
| EP-0689462-A1 | IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS | NYCOMED IMAGING AS (NO) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021302-A1 | IMPROVEMENTS IN OR RELATING TO CONTRAST AGENTS | HOLMES, MICHAEL, JOHN (GB) | 1994-09-29 | — | — | WO | claimed |
| US-3997659-A | PEROXIDE AND PEROXYDISULFATE OR PEROXYDIPHOSPHATE | THE PROCTER & GAMBLE COMPANY (US) | 1976-12-14 | — | — | US | claimed |