Abt 737

Abt 737

SCHEMBL158942

CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC3)cc2)cc1[N+](=O)[O-]

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 18/20 1.00
BCL2 P10415 9/20 1.00
MDM4 O15151 1/20 1.00
BCL2L11 O43521 1/20 1.00
TP53 P04637 1/20 1.00
BID P55957 1/20 1.00
BAX Q07812 1/20 1.00
MCL1 Q07820 1/20 1.00
ASPH Q12797 1/20 1.00
BECN1 Q14457 1/20 1.00
BAK1 Q16611 1/20 1.00
BCL2L2 Q92843 1/20 1.00
BAD Q92934 1/20 1.00
BBC3 Q9BXH1 1/20 1.00
HDAC3 O15379 2/20 0.88
HDAC4 P56524 2/20 0.88
HDAC1 Q13547 2/20 0.88
HDAC7 Q8WUI4 2/20 0.88
HDAC2 Q92769 2/20 0.88
HDAC10 Q969S8 2/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Abt 737 SCHEMBL170470 1.00 BCL2L1 (1.00) BCL2L1BCL2MDM4BCL2L11TP53
Abt 737 SCHEMBL29355185 1.00 BCL2L1 (1.00) BCL2L1BCL2MDM4BCL2L11TP53
Abt 737 SCHEMBL1541072 1.00 BCL2L1 (1.00) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1540670 0.97 BCL2L1 (0.93) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1540214 0.96 BCL2L1 (0.92) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1540387 0.96 BCL2L1 (0.92) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1540510 0.96 BCL2L1 (1.00) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1540736 0.96 BCL2L1 (1.00) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL1541579 0.95 BCL2L1 (0.91) BCL2L1BCL2MDM4BCL2L11TP53
SCHEMBL26648550 0.95 BCL2L1 (0.91) BCL2L1BCL2MDM4BCL2L11TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 4582 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146233-A1 HIF-1a STABILIZATION FOR TISSUE REGENERATION THE UNIVERSITY OF HONG KONG (CN) 2026-05-28 US claimed
EP-3429570-B1 COMBINATIONS OF LSD1 INHIBITORS FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES ORYZON GENOMICS SA (ES) 2026-05-20 EP claimed
CN-122028938-A Pharmaceutical combination comprising an anti-CD 37 antibody maytansinoid conjugate and a BCL2 inhibitor or PI3K inhibitor 德彪药业国际股份公司 2026-05-12 CN claimed
CN-122028920-A Method for treating hematological cancer 丹娜-法伯癌症研究院 2026-05-12 CN claimed
US-20260124242-A1 EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES FROM LIQUID TUMORS AND THERAPEUTIC USES THEREOF IOVANCE BIOTHERAPEUTICS INC (US) 2026-05-07 US claimed
EP-4727563-A1 AGENTS FOR USE IN A METHOD OF TREATING AN ACUTE LIVER DISEASE SUBJECT Beatson Institute for Cancer Research (GB) 2026-04-22 EP claimed
US-12605460-B2 Stem cell-nano drug delivery system complex, use thereof and method for preparing the same GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2026-04-21 US claimed
EP-4719403-A1 METHODS OF TREATING CANCER IN BCL2 INHIBITOR NAIVE SUBJECTS Curis, Inc. (US) 2026-04-08 EP claimed
US-12595517-B2 Method to treat and stratify a patient suffering from a cancer INSERM (INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2026-04-07 US claimed
EP-4714447-A1 DRUG COMBINATIONS OF BCL-XL INHIBITORS FOR TREATMENT OF CANCER Stichting Amsterdam UMC (NL) 2026-03-25 EP claimed
US-20100028889-A1 COMPANION DIAGNOSTIC ASSAYS FOR CANCER THERAPY ABBOTT LABORATORIES (US) 2010-02-04 US claimed
US-7642260-B2 N-acylsulfonamide derivatives; BCL-X1 protein inhibitors; anticarcinogenic agents; bladder cancer; for example, N-(4-(4-((4'-chloro(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)-propyl)amino)-3-nitrobenzenesulfonamide ABBOTT LABORATORIES, INC. (US) 2010-01-05 US claimed
US-20090176785-A1 METHOD OF TREATING ARTHRITIS ABBOTT LABORATORIES (US) 2009-07-09 US claimed
US-20080199873-A1 Companion diagnostic assays for cancer therapy ABBOTT LABORATORIES 2008-08-21 US claimed
US-20080182845-A1 METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION ABBOTT LABORATORIES (US) 2008-07-31 US claimed
US-20070072860-A1 N-acylsulfonamide derivatives; BCL-X1 protein inhibitors; anticarcinogenic agents; bladder cancer; for example, N-(4-(4-((4'-chloro(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzoyl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)-propyl)amino)-3-nitrobenzenesulfonamide ABBOTT LABORATORIES 2007-03-29 US claimed
US-20070015787-A1 Apoptosis promoters ABBVIE INC. 2007-01-18 US claimed
US-20060258657-A1 Apoptosis promoters ABBVIE INC. 2006-11-16 US claimed
US-20060128706-A1 Apoptosis promoters ABBVIE INC. 2006-06-15 US claimed
US-20050159427-A1 N-acylsulfonamide apoptosis promoters ABBOTT LABORATORIES 2005-07-21 US claimed