SCHEMBL15899887

SCHEMBL15899887

CC1CN(c2ccc(Nc3ncc4cc(C#N)n(C5CCCC5)c4n3)nc2)CCN1C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 7/20 0.67
CDK1 P06493 4/20 0.67
CDK4 P11802 16/20 0.56
CCND1 P24385 11/20 0.54
CCND3 P30281 6/20 0.54
CCND2 P30279 5/20 0.54
CCNA2 P20248 4/20 0.53
CDK6 Q00534 3/20 0.53
GAK O14976 1/20 0.53
CCNT1 O60563 1/20 0.53
FECH P22830 1/20 0.53
CDK9 P50750 1/20 0.53
CDK16 Q00536 1/20 0.53
MAP3K1 Q13233 1/20 0.53
CAMK2G Q13555 1/20 0.53
CAMK2D Q13557 1/20 0.53
Q6ZSR9 Q6ZSR9 1/20 0.53
PRKD2 Q9BZL6 1/20 0.53
SIK2 Q9H0K1 1/20 0.53
CCNA1 P78396 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1995414 0.90 CDK2 (0.62) CDK2CDK1CDK4CCND1CCND3
SCHEMBL2023942 0.85 CDK4 (0.76) CDK2CDK1CDK4CCND1CCND3
SCHEMBL2023946 0.85 CDK4 (0.76) CDK2CDK1CDK4CCND1CCND3
SCHEMBL305495 0.83 CDK2 (0.72) CDK2CDK1CDK4CCND1CCND3
SCHEMBL1994429 0.81 CDK2 (0.68) CDK2CDK1CDK4CCND1CCND3
SCHEMBL1995714 0.81 CDK2 (0.77) CDK2CDK1CDK4CCND1CCND3
SCHEMBL28734786 0.81 CDK4 (0.57) CDK2CDK1CDK4CCND1CCND3
SCHEMBL303554 0.80 CDK2 (1.00) CDK2CDK1CDK4CCND1CCND3
SCHEMBL29507585 0.80 CDK2 (1.00) CDK2CDK1CDK4CCND1CCND3
SCHEMBL1989922 0.80 CDK2 (0.65) CDK2CDK1CDK4CCND1CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331547-B1 PYRROLOPYRIMIDINE COMPOUNDS AS CDK INHIBITORS NOVARTIS AG (CH) 2014-07-30 EP disclosed