⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL207029 | 0.71 | — | — | |
| SCHEMBL208652 | 0.71 | — | — | |
| SCHEMBL2009985 | 0.65 | — | — | |
| SCHEMBL6208974 | 0.64 | — | — | |
| SCHEMBL208590 | 0.64 | — | — | |
| SCHEMBL5468613 | 0.64 | GSK3A (0.40) | — | |
| SCHEMBL3909589 | 0.61 | — | — | |
| SCHEMBL193801 | 0.61 | — | — | |
| SCHEMBL2916689 | 0.61 | — | — | |
| SCHEMBL4808810 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9388198-B2 | Heterocyclic amide derivatives as P2X7 receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-07-12 | — | — | US | disclosed |
| EP-2956457-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2015-12-23 | — | — | EP | disclosed |
| US-20150361097-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2015-12-17 | — | — | US | disclosed |
| WO-2014115078-A1 | HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-07-31 | — | — | WO | disclosed |