Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14652102 | 0.82 | SMYD3 (0.40) | EPHX1KMT2AMEN1LMNASMN1; SMN2 | |
| SCHEMBL15906224 | 0.80 | EPHX1 (0.46) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL15906222 | 0.80 | EPHX1 (0.46) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL8006185 | 0.79 | EPHX1 (0.52) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL14655005 | 0.78 | SMYD3 (0.40) | EPHX1KMT2ALMNASMYD3L3MBTL1 | |
| SCHEMBL13472172 | 0.77 | EPHX1 (0.43) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL12385840 | 0.76 | EPHX1 (0.53) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL12545637 | 0.76 | EPHX1 (0.53) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL15199116 | 0.76 | EPHX1 (0.53) | EPHX1KMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL21126146 | 0.76 | EPHX1 (0.42) | EPHX1KMT2AMEN1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791257-B2 | Substituted pyrrolotriazines as protein kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-29 | — | — | US | disclosed |