Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14652106 | 0.82 | MME (0.41) | MMECSNK2A2CSNK2A1SSTR4 | |
| SCHEMBL14655006 | 0.79 | MME (0.42) | EPHX1MMECSNK2A2CSNK2A1SSTR4 | |
| SCHEMBL15906215 | 0.77 | EPHX1 (0.48) | EPHX1ALDH1A1ADRA2ASMN1; SMN2NPC1 | |
| SCHEMBL25019291 | 0.74 | EPHX1 (0.50) | EPHX1ALDH1A1ADRA2ASMN1; SMN2NPC1 | |
| SCHEMBL25676341 | 0.74 | EPHX1 (0.50) | EPHX1ALDH1A1ADRA2ASMN1; SMN2NPC1 | |
| SCHEMBL15906230 | 0.74 | EPHX1 (0.50) | EPHX1ALDH1A1ADRA2ASMN1; SMN2NPC1 | |
| SCHEMBL15906204 | 0.74 | EPHX1 (0.50) | EPHX1MMEALDH1A1ADRA2ASMN1; SMN2 | |
| SCHEMBL15906234 | 0.74 | EPHX1 (0.50) | EPHX1MMEALDH1A1ADRA2ASMN1; SMN2 | |
| SCHEMBL15906214 | 0.73 | SMYD3 (0.54) | EPHX1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL13649892 | 0.73 | SMYD3 (0.54) | EPHX1SMN1; SMN2NPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791257-B2 | Substituted pyrrolotriazines as protein kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-07-29 | — | — | US | disclosed |