SCHEMBL15906306

SCHEMBL15906306

Nc1ncnc2c1ncn2C1OC2COP(O)(=S)O[C@H]2[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 1.00
MEN1 O00255 1/20 1.00
ALDH1A1 P00352 1/20 1.00
STING1 Q86WV6 15/20 0.80
LMNA P02545 2/20 0.78
RAPGEF3 O95398 2/20 0.78
GMNN O75496 1/20 0.78
BLM P54132 1/20 0.78
NPSR1 Q6W5P4 1/20 0.78
RAPGEF4 Q8WZA2 1/20 0.78
RXFP1 Q9HBX9 1/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1106650 1.00 KMT2A (1.00) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL1106664 1.00 KMT2A (1.00) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL29515507 1.00 KMT2A (1.00) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL4159569 1.00 KMT2A (1.00) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL10098850 1.00 KMT2A (1.00) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL29368433 0.96 KMT2A (0.93) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL29478470 0.96 KMT2A (0.93) KMT2AMEN1ALDH1A1STING1LMNA
Ammonia Solution, Strong SCHEMBL29465897 0.95 KMT2A (0.91) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL29712629 0.94 KMT2A (0.88) KMT2AMEN1ALDH1A1STING1LMNA
SCHEMBL5151491 0.89 KMT2A (0.80) KMT2AMEN1ALDH1A1STING1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765844-B1 PURINE NUCLEOTIDE DERIVATIVES SOLVELL AS (NO) 2014-07-30 EP disclosed