Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 20/20 | 0.80 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.73 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444384 | 0.89 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443742 | 0.87 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443599 | 0.84 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443157 | 0.83 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443440 | 0.82 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL443033 | 0.82 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL444891 | 0.80 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL444458 | 0.79 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL442448 | 0.79 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 | |
| SCHEMBL444359 | 0.79 | HDAC8 (1.00) | HDAC8HDAC6HDAC1HDAC7HDAC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613775-B1 | N-HYDROXY-BENZAMIDES FOR THE TREATMENT OF CANCER | HOFFMANN LA ROCHE (CH) | 2014-07-30 | — | — | EP | disclosed |