Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12029325 | 0.85 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029289 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029302 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029305 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029284 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL15906673 | 0.77 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029299 | 0.76 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029050 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12661885 | 0.70 | PARP1 (0.53) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 | |
| SCHEMBL12029293 | 0.69 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1ALOX15TSHRMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344475-B1 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2014-07-30 | — | — | EP | disclosed |