Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | KIT | P10721 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18323206 | 0.94 | ABL1 (0.53) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL15907277 | 0.91 | ABL1 (0.56) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL15907237 | 0.88 | ABL1 (0.51) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL18323137 | 0.85 | ABL1 (0.64) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL15907295 | 0.84 | ABL1 (0.60) | ABL1FGFR1KDRKIT | |
| SCHEMBL15907320 | 0.83 | RET (0.46) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL18323193 | 0.82 | ABL1 (0.58) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL15907248 | 0.81 | ABL1 (0.48) | ABL1RETFGFR1KDRKIT | |
| SCHEMBL18323208 | 0.78 | ABL1 (0.69) | ABL1FGFR1KDRKIT | |
| SCHEMBL15907165 | 0.78 | KIT (0.57) | ABL1RETFGFR1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140213592-A1 | Protein Kinase Inhibitors (Variants), Use Thereof in Treating Oncological Diseases and a Pharmaceutical Composition Based Thereon | OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYOU "FUSION PHARMA" (RU) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213592-A1 | Protein Kinase Inhibitors (Variants), Use Thereof in Treating Oncological Diseases and a Pharmaceutical Composition Based Thereon | ABL1, ABL2, MAP3K6 | ABL1 1/4885RET 45/4885FGFR1 199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.