Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL159101 | 1.00 | GRM5 (0.49) | GRM5KCNH2CASP3SENP8SENP7 | |
| SCHEMBL158839 | 0.93 | GRM5 (0.58) | GRM5KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL158838 | 0.93 | GRM5 (0.58) | GRM5KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL15293375 | 0.89 | GRM5 (0.49) | GRM5KCNH2MEN1KMT2AKDM4E | |
| SCHEMBL1503817 | 0.78 | ELANE (0.41) | GRM5MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL1503816 | 0.78 | ELANE (0.41) | GRM5MEN1KMT2AKDM4ERAB9A | |
| SCHEMBL157831 | 0.76 | GRM5 (0.63) | GRM5KCNH2 | |
| SCHEMBL158393 | 0.76 | GRM5 (0.78) | GRM5 | |
| SCHEMBL157684 | 0.72 | GAA (0.47) | GRM5MEN1KMT2AKDM4ENPC1 | |
| SCHEMBL157685 | 0.72 | GAA (0.47) | GRM5MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9090632-B2 | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090632-B2 | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-07-28 | — | — | US | disclosed |
| US-9090632-B2 | Bicyclic oxazole and thiazole compounds and their use as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-07-28 | — | — | US | disclosed |
| US-20130261107-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130261107-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-10-03 | — | — | US | disclosed |
| US-20130261107-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-10-03 | — | — | US | disclosed |
| EP-2611298-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | Vanderbilt University (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031024-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130261107-A1 | BICYCLIC OXAZOLE AND THIAZOLE COMPOUNDS AND THEIR USE AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM1 | GRM5 1/4885KCNH2 1714/4885CASP3 3560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.