Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.47 |
| ▸ | KDR | P35968 | 13/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 11/20 | 0.47 |
| ▸ | FLT1 | P17948 | 6/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15910800 | 1.00 | FGFR1 (0.47) | FGFR1KDRPDGFRBFLT1FLT3 | |
| SCHEMBL3381313 | 0.95 | FGFR1 (0.52) | FGFR1KDRPDGFRBFLT1FLT3 | |
| SCHEMBL3381326 | 0.95 | FGFR1 (0.52) | FGFR1KDRPDGFRBFLT1FLT3 | |
| SCHEMBL3378274 | 0.91 | FGFR1 (0.58) | FGFR1KDRPDGFRBFLT1CHEK1 | |
| SCHEMBL3381041 | 0.91 | FGFR1 (0.58) | FGFR1KDRPDGFRBFLT1CHEK1 | |
| SCHEMBL14795509 | 0.87 | FGFR1 (0.47) | FGFR1KDRPDGFRBFLT1FLT3 | |
| SCHEMBL14795445 | 0.86 | FGFR1 (0.61) | FGFR1KDRPDGFRBFLT1CHEK1 | |
| SCHEMBL14795447 | 0.86 | FGFR1 (0.61) | FGFR1KDRPDGFRBFLT1CHEK1 | |
| SCHEMBL14796127 | 0.85 | FGFR1 (0.46) | FGFR1KDRPDGFRBFLT1FLT3 | |
| SCHEMBL14796018 | 0.85 | FGFR1 (0.46) | FGFR1KDRPDGFRBFLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2762475-A1 | Pharmaceutically acceptable salts of quinolinone compounds and their medical use | Novartis Vaccines and Diagnostics, Inc. (US) | 2014-08-06 | — | — | EP | disclosed |