Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 19/20 | 0.75 |
| ▸ | PIM2 | Q9P1W9 | 15/20 | 0.75 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913534 | 1.00 | PIM1 (0.75) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL15913533 | 1.00 | PIM1 (0.75) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL13736979 | 0.89 | PIM1 (0.76) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL13833559 | 0.86 | PIM1 (1.00) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL13833203 | 0.81 | PIM1 (1.00) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL13833207 | 0.81 | PIM1 (1.00) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL15913724 | 0.79 | PIM1 (0.72) | PIM1PIM2PIM3KCNH2 | |
| Trifluoroacetic Acid SCHEMBL13738016 | 0.77 | PIM1 (0.87) | PIM1PIM2PIM3KCNH2 | |
| SCHEMBL13833606 | 0.75 | PIM1 (1.00) | PIM1PIM2 | |
| Trifluoroacetic Acid SCHEMBL15914107 | 0.74 | PIM1 (0.67) | PIM1PIM2PIM3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187486-B2 | Bicyclic pyridazine compounds as Pim inhibitors | AMGEN INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140221344-A1 | Bicyclic Pyridazine Compounds as PIM Inhibitors | AMGEN INC. | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221344-A1 | Bicyclic Pyridazine Compounds as PIM Inhibitors | PIM1, PIM2, PIM3 | PIM1 1/4885PIM2 2/4885PIM3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.