Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439434 | 0.81 | JAK3 (0.44) | HRH4HTTJAK3 | |
| SCHEMBL16040576 | 0.71 | HRH4 (0.60) | HRH4HTT | |
| SCHEMBL16702828 | 0.71 | KDM4E (0.57) | JAK3 | |
| SCHEMBL13354928 | 0.71 | CYP2D6 (0.52) | HTT | |
| SCHEMBL29124644 | 0.71 | — | — | |
| SCHEMBL28070643 | 0.71 | MAPT (0.48) | HTT | |
| Hydrochloric Acid SCHEMBL2797503 | 0.70 | CYP2D6 (0.51) | HTT | |
| Hydrochloric Acid SCHEMBL26600657 | 0.70 | CYP2D6 (0.51) | HTT | |
| SCHEMBL29124725 | 0.68 | MEN1 (0.31) | — | |
| SCHEMBL14334727 | 0.68 | HRH3 (0.50) | HRH4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9187486-B2 | Bicyclic pyridazine compounds as Pim inhibitors | AMGEN INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140221344-A1 | Bicyclic Pyridazine Compounds as PIM Inhibitors | AMGEN INC. | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221344-A1 | Bicyclic Pyridazine Compounds as PIM Inhibitors | PIM1, PIM2, PIM3 | HRH4 4231/4885HTT 3207/4885JAK3 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.