SCHEMBL15914679

SCHEMBL15914679

COc1ccc(-c2ccc3nc(-c4ccc(C#N)cc4)c(CCN4CCCN(C)CC4)n3c2)cc1OC

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 6/20 0.42
▸ SLC2A2 P11168 1/20 0.41
▸ MCHR1 Q99705 1/20 0.41
▸ HRH3 Q9Y5N1 3/20 0.39
▸ KCNK3 O14649 3/20 0.38
▸ KCNK9 Q9NPC2 3/20 0.38
▸ PRNP P04156 3/20 0.38
▸ CHEK1 O14757 1/20 0.38
▸ KDM1A O60341 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819136 0.92 SLC2A1 (0.52) SLC2A1KCNK3KCNK9
SCHEMBL15914229 0.91 SLC2A2 (0.45) SLC2A1SLC2A2MCHR1KCNK3KCNK9
SCHEMBL15914748 0.89 SLC2A1 (0.49) SLC2A1SLC2A2HRH3KCNK3KCNK9
SCHEMBL15914576 0.89 SLC2A1 (0.49) SLC2A1SLC2A2HRH3KCNK3KCNK9
SCHEMBL15914730 0.87 SLC2A1 (0.44) SLC2A1SLC2A2HRH3KCNK3KCNK9
SCHEMBL15914584 0.85 SLC2A1 (0.43) SLC2A1SLC2A2HRH3KCNK3KCNK9
SCHEMBL15914939 0.85 SLC2A1 (0.60) SLC2A1SLC2A2
SCHEMBL15914613 0.85 SLC2A1 (0.60) SLC2A1SLC2A2
SCHEMBL12818957 0.83 SLC2A1 (0.49) SLC2A1KCNK3KCNK9
SCHEMBL15914075 0.83 SLC2A1 (0.49) SLC2A1SLC2A2KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885SLC2A2 1610/4885MCHR1 1360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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