SCHEMBL15914693

SCHEMBL15914693

Cc1ccc(-c2ccc3nc(-c4ccc(C#N)cc4)c(CCN4CCNC(=O)C4)n3c2)cc1C

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 10/20 0.51
▸ SLC2A2 P11168 4/20 0.46
▸ KCNK3 O14649 2/20 0.37
▸ KCNK9 Q9NPC2 2/20 0.37
▸ PRNP P04156 1/20 0.37
▸ GRIA1 P42261 3/20 0.36
▸ CTSS P25774 1/20 0.35
▸ CTSK P43235 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12819176 0.91 SLC2A1 (0.61) SLC2A1SLC2A2KCNK3KCNK9
SCHEMBL15914942 0.86 SLC2A1 (0.53) SLC2A1SLC2A2KCNK3KCNK9
SCHEMBL15915224 0.84 SLC2A2 (0.47) SLC2A1SLC2A2KCNK3KCNK9PRNP
SCHEMBL15914730 0.82 SLC2A1 (0.44) SLC2A1SLC2A2KCNK3KCNK9PRNP
SCHEMBL12819125 0.79 SLC2A1 (0.54) SLC2A1SLC2A2KCNK3KCNK9
SCHEMBL12818980 0.79 SLC2A1 (0.79) SLC2A1SLC2A2
SCHEMBL15914692 0.79 SLC2A1 (0.38) SLC2A1SLC2A2KCNK3KCNK9PRNP
SCHEMBL12819283 0.78 SLC2A1 (0.64) SLC2A1SLC2A2KCNK3KCNK9
SCHEMBL12818929 0.77 SLC2A1 (0.63) SLC2A1SLC2A2
SCHEMBL12819010 0.77 SLC2A1 (0.51) SLC2A1SLC2A2KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY EMBLEM TECHNOLOGY TRANSFER GMBH (DE) 2014-08-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140221354-A1 IMIDAZO [1,2-a]PYRIDINE COMPOUNDS FOR USE IN THERAPY HIF1A, HIF1AN, EGLN3 SLC2A1 1235/4885SLC2A2 1610/4885KCNK3 2267/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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