Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 20/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15924900 | 0.87 | MDM2 (0.63) | MDM2 | |
| SCHEMBL17314883 | 0.87 | MDM2 (0.81) | MDM2 | |
| SCHEMBL17314858 | 0.87 | MDM2 (0.81) | MDM2 | |
| SCHEMBL15921831 | 0.81 | MDM2 (0.42) | MDM2 | |
| SCHEMBL15930806 | 0.76 | MDM2 (1.00) | MDM2 | |
| SCHEMBL17314045 | 0.76 | MDM2 (1.00) | MDM2 | |
| SCHEMBL17314852 | 0.76 | MDM2 (0.80) | MDM2 | |
| SCHEMBL17314674 | 0.76 | MDM2 (0.80) | MDM2 | |
| SCHEMBL15924899 | 0.75 | MDM2 (0.82) | MDM2 | |
| SCHEMBL17314885 | 0.75 | MDM2 (0.82) | MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2951180-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014120748-A1 | 2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | WO | disclosed |