SCHEMBL15924908

SCHEMBL15924908

Nc1cnc(-c2ccc(-c3ccccc3)c(Cl)c2F)cn1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.78
ALOX5AP P20292 17/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15915280 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15915227 0.80 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15924407 0.78 FEN1 (0.70) FEN1ALOX5AP
SCHEMBL15924660 0.75 FEN1 (0.81) FEN1ALOX5AP
SCHEMBL15917495 0.73 FEN1 (0.70) FEN1ALOX5AP
Hydrochloric Acid SCHEMBL17362134 0.73 FEN1 (0.62) FEN1ALOX5AP
SCHEMBL15924455 0.73 FEN1 (0.65) FEN1ALOX5AP
SCHEMBL15912845 0.73 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL934072 0.73 FEN1 (0.62) FEN1ALOX5AP
SCHEMBL29817861 0.73 FEN1 (0.62) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2951170-A2 FLAP MODULATORS Janssen Pharmaceutica, N.V. (BE) 2015-12-09 EP disclosed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed