Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.46 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.44 |
| ▸ | BRAF | P15056 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314497 | 0.91 | KDR (0.43) | MAPK14KDRPDGFRAKITFGFR2 | |
| SCHEMBL2314489 | 0.91 | KDR (0.43) | MAPK14KDRPDGFRAKITFGFR2 | |
| SCHEMBL4458374 | 0.88 | BRAF (0.45) | MAPK14KDRPDGFRAKITFGFR2 | |
| SCHEMBL29837315 | 0.87 | KDR (0.45) | MAPK14KDRPDGFRAKITFGFR2 | |
| SCHEMBL2973081 | 0.87 | KDR (0.45) | MAPK14KDRPDGFRAKITFGFR2 | |
| SCHEMBL13822027 | 0.86 | KDR (0.59) | KDRBRAF | |
| SCHEMBL2932337 | 0.82 | BRAF (0.65) | KDRBRAF | |
| SCHEMBL2932789 | 0.81 | MAPT (0.43) | — | |
| SCHEMBL28706536 | 0.79 | KDR (0.43) | KDRPDGFRABRAF | |
| SCHEMBL29662384 | 0.79 | KDR (0.43) | KDRPDGFRABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |