Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.71 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925272 | 0.83 | BRAF (0.69) | BRAFRAF1KDR | |
| SCHEMBL3757066 | 0.83 | BRAF (1.00) | BRAF | |
| SCHEMBL3763280 | 0.74 | BRAF (1.00) | BRAFKDR | |
| SCHEMBL29844360 | 0.71 | MAPK14 (0.67) | BRAFKDR | |
| SCHEMBL23201782 | 0.71 | MAPK14 (0.67) | BRAFKDR | |
| SCHEMBL15925246 | 0.68 | BRAF (0.54) | BRAF | |
| SCHEMBL15925266 | 0.67 | BRAF (0.70) | BRAF | |
| SCHEMBL15925268 | 0.67 | BRAF (0.51) | BRAFRAF1KDR | |
| SCHEMBL3759453 | 0.66 | BRAF (0.72) | BRAFKDR | |
| SCHEMBL3759436 | 0.66 | BRAF (1.00) | BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |