Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.81 |
| ▸ | HCK | P08631 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935839 | 0.90 | BRAF (1.00) | BRAF | |
| SCHEMBL2933258 | 0.83 | BRAF (0.73) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2928357 | 0.81 | BRAF (1.00) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL3757074 | 0.81 | BRAF (1.00) | BRAF | |
| SCHEMBL13822067 | 0.79 | BRAF (0.78) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL12522939 | 0.79 | BRAF (0.78) | BRAF | |
| SCHEMBL3062162 | 0.79 | BRAF (0.68) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL2934892 | 0.78 | BRAF (1.00) | BRAF | |
| SCHEMBL2936555 | 0.77 | BRAF (0.78) | BRAFHCKSRCMAPK12MAPK14 | |
| SCHEMBL15681376 | 0.75 | BRAF (0.82) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-B1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2014-08-06 | — | — | EP | disclosed |