Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 6/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1877178 | 0.91 | CCR1 (0.43) | CCR1RXFP1MAPTNAMPTLMNA | |
| SCHEMBL12670782 | 0.79 | CCR1 (0.44) | CCR1RXFP1MAPTNAMPTLMNA | |
| SCHEMBL1135677 | 0.79 | CCR1 (0.57) | CCR1RORC | |
| SCHEMBL1886533 | 0.77 | CCR1 (0.58) | CCR1LMNAKDM4EHTTGAA | |
| SCHEMBL1874628 | 0.75 | CCR1 (0.57) | CCR1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL1875936 | 0.75 | KDM4E (0.41) | CCR1LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL1880010 | 0.74 | CCR1 (0.44) | CCR1LMNAKDM4EHTTRORC | |
| SCHEMBL1896198 | 0.73 | CCR1 (0.57) | CCR1MAPTLMNARORC | |
| SCHEMBL1874395 | 0.73 | CCR1 (0.56) | CCR1MAPTLMNARORCTP53 | |
| SCHEMBL1135767 | 0.72 | CCR1 (0.73) | CCR1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493875-B1 | HETEROCYCLIC COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-08-06 | — | — | EP | disclosed |