Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | CYP8B1 | Q9UNU6 | 2/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15913069 | 0.91 | MAPT (0.77) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15927746 | 0.91 | MAPT (0.77) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14764451 | 0.89 | MAPT (0.77) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL15928329 | 0.89 | MAPT (0.77) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19730460 | 0.87 | MAPT (0.80) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL12240584 | 0.87 | MAPT (0.80) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20710109 | 0.84 | MAPT (0.66) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14044074 | 0.80 | MAPT (0.66) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23678506 | 0.78 | MAPT (0.80) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL23355483 | 0.78 | MAPT (0.80) | MAPTLMNAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | UNIV JOHNS HOPKINS (US) | 2016-09-15 | — | — | US | disclosed |
| US-9346791-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | THE JOHNS HOPKINS UNIVERSITY | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264556-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | MAPT 3556/4885LMNA 4868/4885ALDH1A1 1448/4885 |
| US-20140221393-A1 | Itraconazole Analogs and Use Thereof | SHH, GLI1, KDR | MAPT 3556/4885LMNA 4868/4885ALDH1A1 1448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.