Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12044679 | 1.00 | KDM4E (0.54) | KDM4ES1PR1ALDH1A1HSD17B10POLB | |
| SCHEMBL27840733 | 0.88 | S1PR1 (0.56) | S1PR1ALDH1A1HPGDCCKBRMEN1 | |
| SCHEMBL1371682 | 0.88 | S1PR1 (0.56) | S1PR1ALDH1A1HPGDCCKBRMEN1 | |
| SCHEMBL1375018 | 0.85 | S1PR1 (0.54) | S1PR1CCKBR | |
| SCHEMBL27923638 | 0.85 | S1PR1 (0.54) | S1PR1CCKBR | |
| SCHEMBL1372404 | 0.85 | S1PR1 (0.64) | KDM4ES1PR1ALDH1A1HPGDMEN1 | |
| SCHEMBL1372408 | 0.85 | S1PR1 (0.64) | KDM4ES1PR1ALDH1A1HPGDMEN1 | |
| SCHEMBL1373075 | 0.84 | S1PR1 (0.58) | S1PR1ALDH1A1CCKBRMEN1LMNA | |
| SCHEMBL1372392 | 0.84 | S1PR1 (0.63) | KDM4ES1PR1ALDH1A1HPGDMEN1 | |
| SCHEMBL13392746 | 0.84 | S1PR1 (0.63) | KDM4ES1PR1ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802692-B2 | Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents | EXELIXIS, INC. (US) | 2014-08-12 | — | — | US | claimed |