SCHEMBL15929672

SCHEMBL15929672

Cc1ccc(S(=O)(=O)c2ccc(Oc3ccc(Oc4ccc(S(=O)(=O)c5ccc(-n6c(=O)n(C)c7ccccc76)cc5)cc4)cc3OC(=O)/C=C/C=C/c3ccccc3)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 6/20 0.38
BRPF1 P55201 6/20 0.38
BRD1 O95696 5/20 0.38
HTT P42858 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.35
TDP1 Q9NUW8 1/20 0.35
KDM4E B2RXH2 2/20 0.33
LMNA P02545 1/20 0.33
HDAC3 O15379 1/20 0.33
HDAC4 P56524 1/20 0.33
HDAC1 Q13547 1/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC10 Q969S8 1/20 0.33
HDAC11 Q96DB2 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
HDAC9 Q9UKV0 1/20 0.33
HDAC5 Q9UQL6 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15929666 0.95 TRIM24 (0.40) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929654 0.85 HTT (0.42) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929670 0.84 TRIM24 (0.40) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929671 0.82 TRIM24 (0.40) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929673 0.82 HTT (0.47) HTTSMN1; SMN2L3MBTL1TDP1KDM4E
SCHEMBL15929690 0.81 TRIM24 (0.46) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929655 0.79 HTT (0.45) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929647 0.79 HTT (0.47) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929656 0.79 NTRK1 (0.46) TRIM24BRPF1BRD1HTTSMN1; SMN2
SCHEMBL15929659 0.79 HTT (0.43) TRIM24BRPF1BRD1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9035287-B2 Polymeric materials for use in metal-oxide-semiconductor field-effect transistors POLYERA CORPORATION (US) 2015-05-19 US disclosed
US-20140217395-A1 Polymeric Materials for Use in Metal-Oxide-Semiconductor Field-Effect Transistors POLYERA CORPORATION (US) 2014-08-07 US disclosed