SCHEMBL159304

SCHEMBL159304

CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCCC1C(=O)Nc1cc2c(N(C)c3ccccc3)ncnc2cc1OC)C(C)(C)C

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.72
XIAP P98170 6/20 0.72
CYP2C9 P11712 2/20 0.72
CYP2C19 P33261 1/20 0.72
BIRC2 Q13490 7/20 0.44
BIRC3 Q13489 3/20 0.44
CSF1R P07333 2/20 0.42
EGFR P00533 1/20 0.42
PDGFRB P09619 1/20 0.42
PDGFRA P16234 1/20 0.42
CASP9 P55211 1/20 0.39
ELANE P08246 2/20 0.39
BIRC7 Q96CA5 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15050851 1.00 CYP3A4 (0.72) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL15050854 1.00 CYP3A4 (0.72) CYP3A4XIAPCYP2C9CYP2C19BIRC2
Hydrochloric Acid SCHEMBL12474171 0.99 CYP3A4 (0.71) CYP3A4XIAPCYP2C9CYP2C19BIRC2
Hydrochloric Acid SCHEMBL12474173 0.99 CYP3A4 (0.71) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL15060403 0.89 CYP3A4 (0.66) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL15060404 0.89 CYP3A4 (0.66) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL158420 0.87 CYP3A4 (0.80) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL156666 0.87 CYP3A4 (0.80) CYP3A4XIAPCYP2C9CYP2C19BIRC2
SCHEMBL156665 0.87 CYP3A4 (0.80) CYP3A4XIAPCYP2C9CYP2C19BIRC2
Hydrochloric Acid SCHEMBL12474169 0.86 CYP3A4 (0.79) CYP3A4XIAPCYP2C9CYP2C19BIRC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611797-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS Hanmi Science Co., Ltd. (KR) 2013-07-10 EP claimed
WO-2012030160-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS HANMI HOLDINGS CO., LTD. (KR) 2012-03-08 WO claimed