Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 10/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | BRD4 | O60885 | 4/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15685084 | 0.90 | HDAC2 (1.00) | HDAC2HDAC1HDAC3BRD4HDAC4 | |
| SCHEMBL15685116 | 0.90 | HDAC2 (1.00) | HDAC2HDAC1HDAC3BRD4HDAC4 | |
| SCHEMBL15685265 | 0.89 | HDAC2 (1.00) | HDAC2HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL15685106 | 0.89 | HDAC2 (0.84) | HDAC2HDAC1HDAC3BRD4HDAC4 | |
| SCHEMBL15685085 | 0.88 | HDAC2 (0.82) | HDAC2HDAC1HDAC3BRD4 | |
| SCHEMBL15685117 | 0.88 | HDAC2 (1.00) | HDAC2HDAC1HDAC3BRD4HDAC4 | |
| SCHEMBL15653071 | 0.87 | HDAC2 (0.76) | HDAC2HDAC1HDAC3 | |
| SCHEMBL15685118 | 0.87 | HDAC2 (1.00) | HDAC2HDAC1BRD4 | |
| SCHEMBL14845701 | 0.82 | KDM4E (0.72) | HDAC2HDAC1 | |
| SCHEMBL18750643 | 0.82 | HDAC2 (0.67) | HDAC2HDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040727-B2 | Histone deacetylase inhibitor of benzamides and use thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-05-26 | — | — | US | disclosed |
| US-20140221431-A1 | NOVEL HISTONE DEACETYLASE INHIBITOR OF BENZAMIDES AND USE THEREOF | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221431-A1 | NOVEL HISTONE DEACETYLASE INHIBITOR OF BENZAMIDES AND USE THEREOF | HDAC2, HDAC1, HDAC5 | HDAC2 1/4885HDAC1 2/4885HDAC3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.