Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL331776 | 0.91 | SMN1; SMN2 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL8253700 | 0.89 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL11990711 | 0.87 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL332743 | 0.87 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL27623414 | 0.84 | MEN1 (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL331351 | 0.83 | SMN1; SMN2 (0.45) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL10252097 | 0.81 | MEN1 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL332114 | 0.81 | SMN1; SMN2 (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL331219 | 0.80 | SMN1; SMN2 (0.43) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 | |
| SCHEMBL333010 | 0.79 | MEN1 (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796287-B2 | Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide | PFIZER INC. (US) | 2014-08-05 | — | — | US | disclosed |