Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 10/20 | 0.71 |
| ▸ | USP2 | O75604 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | OSBP | P22059 | 1/20 | 0.52 |
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.52 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | INPP5D | Q92835 | 1/20 | 0.49 |
| ▸ | CDC25A | P30304 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918378 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL289077 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL6302509 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL15935854 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL288394 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL3425844 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL9454951 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL2216946 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL10389496 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 | |
| SCHEMBL19837228 | 1.00 | NPC1L1 (0.71) | NPC1L1USP2LMNAMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221353-A1 | Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer | AFFICHEM (FR) | 2014-08-07 | — | — | US | disclosed |