Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | RXRB | P28702 | 3/20 | 0.35 |
| ▸ | RXRG | P48443 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935758 | 0.89 | PDE4B (0.44) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL17290172 | 0.88 | PDE4B (0.47) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL15935755 | 0.88 | PDE4B (0.44) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL17290175 | 0.87 | PDE4B (0.48) | PDE4BPDE4DSRD5A2BCHEACHE | |
| SCHEMBL15935818 | 0.86 | PDE4B (0.42) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL17290108 | 0.85 | PDE4B (0.47) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL15935753 | 0.85 | PDE4B (0.41) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL15935762 | 0.84 | PDE4B (0.41) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL15935752 | 0.82 | PDE4B (0.42) | PDE4BPDE4DSRD5A2RXRARXRB | |
| SCHEMBL15935751 | 0.82 | PDE4B (0.43) | PDE4BPDE4DSRD5A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014117948-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2014-08-07 | — | — | WO | disclosed |