SCHEMBL15935892

SCHEMBL15935892

O=C(NCC(F)(F)F)Nc1cncc(-c2cnc3cc(-c4cn[nH]c4)ccn23)c1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FGFR3 P22607 19/20 0.73
KDR P35968 17/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3324454 0.86 FGFR3 (0.80) FGFR3KDR
SCHEMBL11925549 0.85 FGFR3 (1.00) FGFR3KDR
Hydrochloric Acid SCHEMBL11908754 0.84 FGFR3 (0.98) FGFR3KDR
SCHEMBL3328267 0.83 FGFR3 (0.77) FGFR3KDR
SCHEMBL11909312 0.83 FGFR3 (1.00) FGFR3KDR
SCHEMBL11929174 0.83 FGFR3 (0.75) FGFR3KDR
SCHEMBL11907524 0.83 FGFR3 (1.00) FGFR3KDR
SCHEMBL11907805 0.83 FGFR3 (1.00) FGFR3KDR
SCHEMBL11925544 0.83 FGFR3 (1.00) FGFR3KDR
Hydrochloric Acid SCHEMBL11909037 0.82 FGFR3 (0.98) FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8796244-B2 Imidazopyridine derivatives as inhibitors of receptor tyrosine kinases ASTEX THERAPEUTICS LTD (GB) 2014-08-05 US disclosed