Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 15/20 | 0.67 |
| ▸ | SPHK2 | Q9NRA0 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15935942 | 1.00 | SPHK1 (0.67) | SPHK1SPHK2POLBMEN1NPC1 | |
| SCHEMBL2743392 | 0.86 | SPHK1 (0.61) | SPHK1SPHK2 | |
| SCHEMBL2743394 | 0.86 | SPHK1 (0.61) | SPHK1SPHK2 | |
| SCHEMBL18978575 | 0.85 | SPHK1 (0.70) | SPHK1SPHK2 | |
| SCHEMBL18978465 | 0.85 | SPHK1 (0.70) | SPHK1SPHK2 | |
| SCHEMBL18978451 | 0.85 | SPHK1 (0.70) | SPHK1SPHK2 | |
| SCHEMBL2343429 | 0.84 | SPHK1 (0.60) | SPHK1SPHK2 | |
| SCHEMBL2343431 | 0.84 | SPHK1 (0.60) | SPHK1SPHK2 | |
| SCHEMBL19732173 | 0.83 | SPHK1 (0.70) | SPHK1SPHK2MEN1KMT2A | |
| SCHEMBL18969861 | 0.82 | SPHK1 (0.80) | SPHK1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014118556-A2 | SELECTIVE INHIBITORS AND ALLOSTERIC ACTIVATORS OF SPHINGOSINE KINASE | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | WO | disclosed |