Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.46 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867282 | 0.85 | RYR2 (0.60) | SIGMAR1ALDH1A1RYR2 | |
| SCHEMBL6867057 | 0.84 | RYR2 (0.51) | SIGMAR1RYR2 | |
| SCHEMBL15935957 | 0.83 | DRD4 (0.51) | SIGMAR1TNFNOD2NOD1ALDH1A1 | |
| SCHEMBL6868322 | 0.81 | RYR2 (0.60) | RYR2 | |
| SCHEMBL6867909 | 0.80 | RYR2 (0.57) | RYR2 | |
| SCHEMBL13302252 | 0.79 | TNF (0.70) | SIGMAR1TNFNOD2NOD1ABCB1 | |
| SCHEMBL15342814 | 0.77 | RYR2 (0.54) | RYR2 | |
| SCHEMBL15327766 | 0.77 | RYR2 (0.54) | RYR2 | |
| Surlorian SCHEMBL29728244 | 0.77 | RYR2 (0.58) | RYR2 | |
| Surlorian SCHEMBL15326996 | 0.77 | RYR2 (0.58) | RYR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764867-A1 | Agents for preventing and treating disorders Involving modulation of the RYR receptors | The Trustees of Columbia University in the City of New York (US) | 2014-08-13 | — | — | EP | claimed |