Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 15/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1875180 | 1.00 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1875181 | 1.00 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1872949 | 0.90 | GRIA2 (0.51) | GRIA2KCNH2GRIA4 | |
| SCHEMBL7795258 | 0.89 | GRIA2 (0.52) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1871828 | 0.89 | GRIA2 (0.50) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1870115 | 0.88 | GRIA2 (0.49) | GRIA2KCNH2 | |
| SCHEMBL1872317 | 0.87 | GRIA2 (0.69) | GRIA2KCNH2GRIA4 | |
| SCHEMBL7788019 | 0.87 | GRIA2 (0.69) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1872315 | 0.87 | GRIA2 (0.69) | GRIA2KCNH2GRIA4 | |
| SCHEMBL1875609 | 0.86 | GRIA2 (0.47) | GRIA2KCNH2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445883-B1 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER (US) | 2014-08-13 | — | — | EP | disclosed |