SCHEMBL15936697

SCHEMBL15936697

Nc1ncc(-c2ccc(-c3ccccc3O)cc2F)cn1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.80
ALOX5AP P20292 16/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15917621 0.89 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15936647 0.85 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL19286167 0.83 FEN1 (0.71) FEN1ALOX5AP
SCHEMBL17367711 0.82 FEN1 (0.85) FEN1ALOX5AP
SCHEMBL20627464 0.82 FEN1 (0.80) FEN1ALOX5AP
SCHEMBL15915772 0.82 FEN1 (0.80) FEN1ALOX5AP
SCHEMBL15916821 0.82 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15932372 0.81 ALOX5AP (1.00) FEN1ALOX5AP
SCHEMBL15917362 0.81 FEN1 (0.72) FEN1ALOX5AP
SCHEMBL15916590 0.79 FEN1 (0.75) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3070085-A1 FLAP MODULATORS Janssen Pharmaceutica N.V. (BE) 2016-09-21 EP disclosed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed