SCHEMBL15936725

SCHEMBL15936725

Nc1cnc(-c2ccc(-c3ccccc3OC3CCCCC3)cc2F)cn1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.82
ALOX5AP P20292 18/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15923106 0.90 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15923108 0.90 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15915818 0.89 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916978 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15918202 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15924762 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL20626970 0.88 FEN1 (0.76) FEN1ALOX5AP
SCHEMBL17362365 0.88 FEN1 (0.82) FEN1ALOX5AP
SCHEMBL15936702 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15915577 0.86 FEN1 (1.00) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3495359-A1 FLAP MODULATORS Janssen Pharmaceutica NV (BE) 2019-06-12 EP disclosed
EP-3070085-B1 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2019-01-09 EP disclosed
EP-3070085-A1 FLAP MODULATORS Janssen Pharmaceutica N.V. (BE) 2016-09-21 EP disclosed
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed