SCHEMBL15936745

SCHEMBL15936745

Nc1cnc(-c2ccc(-c3ccccc3C(O)O)cc2F)cn1

nearest known ligand 0.78

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FEN1 P39748 20/20 0.78
ALOX5AP P20292 18/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15915427 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15916253 0.88 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15915905 0.87 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15918173 0.86 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15936704 0.85 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15917145 0.84 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL21089174 0.84 FEN1 (0.69) FEN1ALOX5AP
SCHEMBL15917227 0.84 FEN1 (1.00) FEN1ALOX5AP
SCHEMBL15915423 0.83 FEN1 (0.84) FEN1ALOX5AP
SCHEMBL15917133 0.82 FEN1 (0.82) FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014121055-A2 FLAP MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-08-07 WO disclosed