Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.42 |
| ▸ | FEN1 | P39748 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31441684 | 1.00 | LRRK2 (0.44) | LRRK2ALOX5APFEN1JAK3FFAR4 | |
| SCHEMBL31441792 | 0.98 | LRRK2 (0.43) | LRRK2ALOX5APFEN1JAK3FFAR4 | |
| SCHEMBL28083358 | 0.98 | LRRK2 (0.43) | LRRK2ALOX5APFEN1JAK3FFAR4 | |
| SCHEMBL7702753 | 0.95 | LRRK2 (0.43) | LRRK2ALOX5APFEN1FFAR4PDE5A | |
| SCHEMBL24344501 | 0.91 | ALOX5AP (0.40) | LRRK2ALOX5APFEN1FFAR4 | |
| SCHEMBL17367699 | 0.85 | ALOX5AP (0.48) | ALOX5APFEN1 | |
| SCHEMBL15916710 | 0.85 | ALOX5AP (0.48) | ALOX5APFEN1 | |
| SCHEMBL15916711 | 0.85 | ALOX5AP (0.48) | ALOX5APFEN1 | |
| SCHEMBL15917169 | 0.83 | NMT1 (0.46) | — | |
| SCHEMBL15915695 | 0.83 | LRRK2 (0.47) | LRRK2ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3495359-A1 | FLAP MODULATORS | Janssen Pharmaceutica NV (BE) | 2019-06-12 | — | — | EP | disclosed |
| EP-3070085-B1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | disclosed |
| EP-3070085-A1 | FLAP MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2016-09-21 | — | — | EP | disclosed |
| WO-2014121055-A2 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-07 | — | — | WO | disclosed |