SCHEMBL159395

SCHEMBL159395

CN[C@@H](C)C(=O)N[C@H](C(=O)N1CCCC1C(=O)Nc1cc2c(Nc3ccc(F)cc3)ncnc2cc1OC)C(C)(C)C

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 0.78
CYP2C9 P11712 2/20 0.78
CYP2C19 P33261 1/20 0.78
XIAP P98170 1/20 0.78
EGFR P00533 11/20 0.45
ERBB2 P04626 8/20 0.45
RAF1 P04049 2/20 0.45
FGFR2 P21802 2/20 0.45
FLT4 P35916 2/20 0.45
KDR P35968 2/20 0.45
TEK Q02763 2/20 0.45
LCK P06239 2/20 0.45
SRC P12931 2/20 0.45
ABL1 P00519 1/20 0.45
RET P07949 1/20 0.45
FLT1 P17948 1/20 0.45
ERBB4 Q15303 7/20 0.44
JAK3 P52333 2/20 0.43
GAK O14976 1/20 0.43
RIPK2 O43353 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15050575 1.00 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL15050576 1.00 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL15050713 0.94 CYP3A4 (0.79) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL160541 0.94 CYP3A4 (0.79) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL160542 0.94 CYP3A4 (0.79) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL15050515 0.93 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
Hydrochloric Acid SCHEMBL15050297 0.93 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
Hydrochloric Acid SCHEMBL15050299 0.93 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL15050512 0.93 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR
SCHEMBL160717 0.93 CYP3A4 (0.78) CYP3A4CYP2C9CYP2C19XIAPEGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2611797-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS Hanmi Science Co., Ltd. (KR) 2013-07-10 EP claimed
WO-2012030160-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS HANMI HOLDINGS CO., LTD. (KR) 2012-03-08 WO claimed
EP-2611797-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS Hanmi Science Co., Ltd. (KR) 2013-07-10 EP disclosed
WO-2012030160-A2 QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS HANMI HOLDINGS CO., LTD. (KR) 2012-03-08 WO disclosed