Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCKR | Q14397 | 9/20 | 0.42 |
| ▸ | GCK | P35557 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12089511 | 0.87 | GCK (0.45) | GCKRGCKMAPTGAATSHR | |
| SCHEMBL18514 | 0.87 | GCK (0.49) | GCKRGCK | |
| SCHEMBL15940 | 0.87 | GCK (0.49) | GCKRGCK | |
| SCHEMBL12078823 | 0.87 | GCK (0.49) | GCKRGCK | |
| SCHEMBL18403 | 0.82 | MAPT (0.51) | MAPTGAATSHRPKMGALR3 | |
| SCHEMBL15855 | 0.75 | GCKR (0.68) | GCKRGCKMAPTGAATSHR | |
| SCHEMBL19488 | 0.74 | GCKR (0.58) | GCKRGCKMAPTGAATSHR | |
| SCHEMBL15835 | 0.74 | GCKR (0.58) | GCKRGCKMAPTGAATSHR | |
| SCHEMBL20260 | 0.74 | GCKR (0.58) | GCKRGCKMAPTGAATSHR | |
| SCHEMBL16568 | 0.73 | GCKR (0.65) | GCKRGCKMAPTPKMJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609081-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | Amgen Inc. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |