Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.59 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.48 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301445 | 0.87 | BRAF (0.52) | BRAFABL1BCR | |
| SCHEMBL13436414 | 0.85 | BRAF (0.48) | BRAFABL1BCRRAF1 | |
| SCHEMBL13436167 | 0.85 | BRAF (0.55) | BRAFABL1BCR | |
| SCHEMBL12398484 | 0.84 | BRAF (0.68) | BRAFABL1BCR | |
| SCHEMBL12398056 | 0.83 | BRAF (0.68) | BRAFABL1BCR | |
| SCHEMBL12397928 | 0.82 | BRAF (0.67) | BRAFABL1BCR | |
| SCHEMBL24251187 | 0.82 | ABL1 (0.61) | BRAFABL1BCRRAF1 | |
| SCHEMBL29551094 | 0.82 | ABL1 (0.61) | BRAFABL1BCRRAF1 | |
| SCHEMBL12397999 | 0.82 | BRAF (0.68) | BRAFABL1BCR | |
| SCHEMBL15869561 | 0.81 | BRAF (0.55) | BRAFABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350052-B1 | ANTIPROLIFERATIVE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2014-08-13 | — | — | EP | disclosed |