Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 7/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15944741 | 0.92 | SMO (0.68) | SMONR1H4MAPK14MEN1KMT2A | |
| SCHEMBL16886088 | 0.91 | SMO (0.69) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944119 | 0.91 | SMO (0.58) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944127 | 0.89 | SMO (0.53) | SMONR1H4MAPK14RAB9ANPC1 | |
| SCHEMBL15944134 | 0.88 | SMO (0.56) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944124 | 0.88 | SMO (0.56) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944125 | 0.88 | SMO (0.56) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944139 | 0.87 | SMO (0.54) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL17613039 | 0.84 | SMO (0.58) | SMOMAPK14RAB9ANPC1ALDH1A1 | |
| SCHEMBL15944122 | 0.84 | SMO (0.51) | SMOMAPK14RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8981149-B2 | Compounds modulating the hedgehog protein signaling pathway, marked forms thereof, and applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-03-17 | — | — | US | disclosed |
| US-20140228441-A1 | Novel Compounds Modulating The Hedgehog Protein Signaling Pathway, Marked Forms Thereof, And Applications | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228441-A1 | Novel Compounds Modulating The Hedgehog Protein Signaling Pathway, Marked Forms Thereof, And Applications | SMO, SHH, GLI1 | SMO 1/4885NR1H4 761/4885MAPK14 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.