SCHEMBL15944932

SCHEMBL15944932

N[C@H]1C[C@H]1c1ccc(NC(=O)C(Cc2ccccc2)NC(=O)OCc2ccccc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 17/20 1.00
MAOA P21397 11/20 1.00
RCOR1 Q9UKL0 6/20 1.00
KDM1B Q8NB78 1/20 1.00
MAOB P27338 4/20 0.98
F2 P00734 2/20 0.61
PRSS1 P07477 2/20 0.61
PRSS2 P07478 2/20 0.61
PRSS3 P35030 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18353842 1.00 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL15944927 1.00 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL2561894 1.00 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
Hydrochloric Acid SCHEMBL14673169 0.99 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL12284283 0.95 KDM1A (0.91) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL12284807 0.94 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL2576847 0.94 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL30816653 0.94 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
SCHEMBL30816605 0.94 KDM1A (1.00) KDM1AMAOARCOR1KDM1BMAOB
Hydrochloric Acid SCHEMBL14673157 0.93 KDM1A (0.98) KDM1AMAOARCOR1KDM1BMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2021-06-17 US disclosed
US-10968213-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2021-04-06 US disclosed
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2019-10-17 US disclosed
US-10414761-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2019-09-17 US disclosed
US-20180162853-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2018-06-14 US disclosed
US-20180162853-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2018-06-14 US disclosed
US-9920047-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-03-20 US disclosed
US-9920047-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-03-20 US disclosed
US-9714241-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-07-25 US disclosed
US-9714241-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2017-07-25 US disclosed
US-9487511-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-11-08 US disclosed
US-9487511-B2 Cyclopropanamine compound and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-11-08 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2016-10-27 US disclosed
US-9278931-B2 Cyclopropaneamine compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-03-08 US disclosed
US-9278931-B2 Cyclopropaneamine compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-03-08 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2015-10-15 US disclosed
US-20140228405-A1 CYCLOPROPANEAMINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-08-14 US disclosed
US-20140228405-A1 CYCLOPROPANEAMINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-08-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190315735-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-20160311808-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-20180162853-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-20210179603-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-20140228405-A1 CYCLOPROPANEAMINE COMPOUND KDM1A, KDM1B, KDM3A KDM1A 1/4885MAOA 101/4885RCOR1 74/4885
US-10968213-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-10414761-B2 Cyclopropanamine compound and use thereof KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885
US-20150291577-A1 CYCLOPROPANAMINE COMPOUND AND USE THEREOF KDM1A, KDM1B, KDM2A KDM1A 1/4885MAOA 493/4885RCOR1 218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.